AI-Powered Drug Discovery
AlmaDyne - AI that maps protein dynamics to uncover new drug targets.
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Our mission is to unlock undruggable targets by mapping the full conformational landscape of disease-relevant proteins in their native biological environment.
Proteins are not static — they breathe, flex, and shift between conformations. Traditional methods photograph only one frozen state, missing the transient pockets where drugs can bind.
AlmaDyne models the full dynamic range of a protein in its native membrane or cytoplasmic environment — not just a crystal structure snapshot.
Transient conformations expose binding sites invisible to conventional structure-based design — opening entirely new druggable surfaces.
AI-designed candidates are tested in vitro and in vivo with Columbia and King's College London, closing the loop back into the model.
Collaborating with leading institutions
for experimental validation
